Erratum: Corrigendum: Ligand-induced conformational changes allosterically activate Toll-like receptor 9
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چکیده
منابع مشابه
Toll-like receptor 2 ligand-induced protection against bacterial endophthalmitis.
BACKGROUND Activation of innate immunity plays a key role in determining the outcome of an infection. Here, we investigated whether Toll-like receptors (TLRs) are involved in retinal innate response and explored the prophylactic use of TLR2 ligand in preventing bacterial endophthalmitis. METHODS C57BL/6 mice were given intravitreal injections of Pam3Cys, a synthetic ligand of TLR2, or vehicle...
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Toll-like receptor 9 (TLR9) is a cellular DNA receptor of the innate immune system. DNA recognition via TLR9 results in an inflammatory reaction, which eventually also activates a Th1-biased adaptive immune attack. In addition to cells of the immune system, TLR9 mRNA and protein are also widely expressed in breast cancer cell lines and in clinical breast cancer specimens. Although synthetic TLR...
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The rate of formation of ribonuclease-S from ribonuclease A by the action of subtilisin was measured at pH 5.5 in the presence and absence of the strongly bound ribonuclease inhibitor, 2’-cytidylate. Presence of the inhibitor in the active center significantly reduced the rate of formation of ribonuclease-S. Since bond 20-21 (and, to a lesser extent, 21-22), the cleavage of which is responsible...
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toll like receptors (tlrs) recognize pathogens and generate an immediate defense response by inducing the production of pro-inflammatory cytokines, which rapidly destroy or limit the pathogens. in their bridging role, tlr downstream signals link innate and adaptive immunity, particularly by mediating dc maturation and activation of pathogen specific t lymphocytes. these pathways lead to the act...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2007
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni1107-1266c